about polynucleotides

Polynucleotide injectables represent a remarkable skincare solution, wielding the ability to transform your skin, ushering in a radiant, youthful appearance you’ve long desired.

These injectables, abbreviated as PN, derive their potency from the fundamental components of DNA.

Through their application, these injections trigger heightened stimulation of collagen and elastin, the pivotal proteins responsible for maintaining skin firmness and elasticity. The DNA fragments attach to the fibroblasts in the dermis, not only making the existing fibroblasts work harder to stimulate collagen and elastin, but increase the number of fibroblasts. With advancing age, the depletion of these proteins leads to the onset of wrinkles and skin laxity. Polynucleotide injectables actively prompt the skin to bolster its production of collagen and elastin, reinstating that coveted youthful resilience.

By enhancing blood circulation, this treatment facilitates the transportation of vital oxygen and nutrients to your skin cells, instilling a vibrant, healthy radiance in your complexion.

Their mechanism extends to expediting the intrinsic healing and rejuvenation processes of your skin. These injectables actively accelerate your skin’s innate ability to repair itself, fostering the regeneration of new, revitalised cells. The result is a smoother, more youthful visage that exudes freshness.

For those grappling with redness and skin irritation, these injectables offer a soothing balm. Their inherent anti-inflammatory properties provide respite, particularly beneficial for individuals with sensitive or rosacea-prone skin.

This versatile treatment extends across various areas, including the face, neck, and décolletage. Addressing concerns such as scars, stretch marks, and notably, the delicate region around the eyes, where thinning or crepey skin and pigmented under-eye circles find effective resolution, avoiding the need for tear trough filler in inappropriate cases.

treatment duration

45 mins

treatment recommended

3-4 treatments 4 weeks apart


numbing cream


every 3-6 months

pricing information

Single area £300
Add an area for £150

Additional areas treated include:
Surgical scars
Stretch marks

technical information

Polynucleotide injectables, often referred to as PN (Polydeoxyribonucleotide), are a class of biologically derived compounds that have garnered attention for their remarkable efficacy in skin rejuvenation. These substances, operate through a complex yet precisely orchestrated mechanism of action within the skin tissue.

1. Stimulation of Collagen Production:

Polynucleotide injectables play a pivotal role in the stimulation of collagen synthesis. Collagen, a structural protein abundant in the skin, confers tensile strength and resilience. With aging, collagen production declines, contributing to the formation of wrinkles and the loss of skin elasticity. Polynucleotides, once introduced into the skin, function as activators of fibroblasts, the cells responsible for collagen generation. This activation prompts an upsurge in collagen production, thereby restoring skin firmness and suppleness.

2. Enhanced Microcirculation:

These injectables exhibit the capacity to increase circulation in the treated area. An increase in the number of tiny blood vessels within the skin microvasculature serves to enhance oxygen and nutrient delivery to the resident skin cells. This heightened nutrient influx aids in cellular metabolism and supports overall skin vitality.

3. Cellular Repair and Regeneration:

Polynucleotide injectables expedite the intrinsic processes of cellular repair and regeneration. By binding to adenosine receptors on the cell membrane, they activate intracellular signalling pathways associated with tissue repair and growth. This mechanism facilitates the repair of damaged skin cells and the proliferation of new, healthy cells, culminating in improved skin texture and appearance.

4. Hydration and Moisture Retention:

Certain polynucleotide injectables possess hygroscopic properties, contributing to enhanced skin hydration. By attracting and retaining moisture molecules within the skin’s extracellular matrix, these substances foster skin plumpness, radiance, and resilience. The result is skin that appears smoother and more youthful.

5. Mitigation of Inflammatory Responses:

Polynucleotides exhibit anti-inflammatory attributes, effectively mitigating localised inflammatory responses within the skin. This characteristic is particularly beneficial for individuals with sensitive or inflammatory skin conditions, as it aids in reducing redness, swelling, and discomfort.

In conclusion, polynucleotide injectables, such as Mastelli’s Plinest or Chroma’s Philart, operate through a multifaceted mechanism involving collagen induction, microcirculation enhancement, cellular repair and regeneration, hydration, and inflammation reduction. These technical intricacies collectively contribute to the observed improvements in skin quality and appearance following the administration of polynucleotide-based treatments, making them a compelling option in the realm of non-invasive skin rejuvenation.

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